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Saturday, June 26, 2021

Higher BMI Means Higher Risk of Heart Disease and Heart Failure

Higher BMI Means Higher Risk of Heart Disease and Heart Failure

The elevated body mass index (BMI) in overweight and obese people isn't just linked to heart failure, it actually causes heart failure.

Normal BMI is from 18 to 25. But for every one-point increase in BMI over 25, the incidence of heart failure goes up 17 percent in overweight people, according to a large-scale, international study of 200,000 people published in June 2013 in PLOS Medicine. This calculation means an estimated 113,000 new cases of heart failure yearly in the United States for each one-unit increase in average BMI.

The 2013 research shed new light on causes of cardiovascular disease, the No. 1 killer in the United States. The international research project brought together 35 studies and more than 130 authors from the ENGAGE (European Network for Genetic and Genomic Epidemiology) Consortium, led by Dr. Tove Fall of the Karolinska Institute in Uppsala Sweden in collaboration with Oxford University in the United Kingdom. 

“We know now that increased adiposity [fat] in itself is dangerous to the heart," said Dr. Fall at the time the study was published. Before, researchers knew there was a link, but couldn't find a direct cause-and-effect relationship between fat and heart disease.

The relationship has to do with connections to the human gene for obesity, known as FTO (fat-mass and obesity-associated gene) which makes people susceptible to obesity and relates to appetite. The FTO gene accounts for one-third of the variation in people's weights as represented by increased BMI. Scientists observed that if you have one copy of the gene, you weigh more than if you have no copies, and if you have two copies of the gene, average weight is even higher in large population studies.

Heart Diseases and BMI

Increased BMI is also connected to 24 cardio-metabolic traits related to heart diseases, based on the 2013 research.

The European researchers found that higher BMI in overweight and obese patients actually caused heart failure, possibly due to increased blood pressure and stress on the heart organ. Elevated BMI also caused higher than normal levels of liver enzymes that indicate fatty liver disease. In addition, high BMI was linked to:

This is particularly concerning because obesity is on the rise around the world.

“This large study provides a more direct link to heart disease using genetic information," said Fall.


Higher BMI Means Higher Risk of Heart Disease and Heart Failure

You Can Take Control of Your Jean Size, But Not Your Genes

“If we normalize our BMI, we have less cardiac risk factors like diabetes and high blood pressure," says Stephanie Moore, MD, a cardiologist at the Massachusetts General Hospital (MGH) Institute for Heart, Vascular and Stroke Care’s Heart Failure and Cardiac Transplant Program in Boston.

While most experts agree that reducing risk factors should translate into fewer cases of heart disease, Dr. Moore is more cautious. “We would have to follow these patients in [the 2013] study longitudinally, or over time, to truly prove that reducing your BMI with genetic predisposition decreases risk," she says.

Moore counsels her patients about their genetics and taking control over their weight. “I do tell my patients, you can’t change your genes, but you can change your jeans size,” says Moore.

To find your BMI, divide your body weight by your height.


Knowing your BMI "is important, because this means that targeting an optimal BMI through various strategies will reduce the risk of having heart failure," said Fall when the European study was published.

He pointed out that there is more to be done, to answer the question of whether weight loss will impact the heart directly. “We only studied the effect of adiposity [fat] on a population level,” he said.

But, he added, “Since we know that weight loss will improve many of the CVD [cardiovascular disease] risk factors and decrease the workload on the heart, it is very plausible that weight loss will decrease the risk of CVD.”

"The most important prescription I can’t write is for weight loss,” says Moore — acknowledging that weight loss is challenging for both physicians and patients.

What can you do to bring your BMI into a healthy range if it's not?

“I refer patients routinely for weight reduction surgery or weight loss programs," says Moore. A healthy diet plays an important role in heart health too. “Vegetables, lean meats, fruit, and daily exercise are the best bet to avoid heart disease,” she adds.

[ By Everyday Health ]

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